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In a 40-week study, the Mounjaro 5-mg, 10-mg, and 15-mg doses were compared to placebo in 475 adults with type 2 diabetes who were also taking insulin glargine. Some study participants were also taking metformin. They had a starting A1C of 8.2% to 8.4%.

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Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Mounjaro with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, or mood changes, hunger, weakness, and feeling jittery.

For people taking Mounjaro and insulin glargine, their A1C was lowered by 2.1% on the 5-mg dose, 2.4% on the 10-mg dose, and 2.3% on the 15-mg dose. For people taking placebo and insulin glargine, their A1C was lowered by 0.9%.