A line graph that shows the mean change in weight for Mounjaro 15 mg or maximum tolerated dose plus metformin and for intensified conventional care plus metformin from baseline to 104 weeks. 392 patients took Mounjaro 15 mg or maximum tolerated dose plus metformin and 391 patients underwent intensified conventional care plus metformin. At the start of treatment, the mean baseline weight was 220.7 lb.
At the primary endpoint (104 weeks), patients taking Mounjaro 15 mg or maximum tolerated dose plus metformin had a mean change in weight of -34.8 lb (-30.5 lb using treatment-regimen estimand) and patients undergoing intensified conventional care plus metformin had a mean change in weight of -14.3 lb (-13.0 lb using treatment-regimen estimand).